Tuesday, May 29, 2012

Top Pediatrics Group Takes Aim at Controversial 'Disorder'

Woody Sims was a gifted boy. His mother said he began reading at a very early age, and he was a bright student in preschool.

To those around him, his development in his early years seemed normal. But in his college essay, Woody, now 18 years old, described a childhood experience marked by "deep fears of loud noises, cooked carrots and handwriting.

"I was over-stimulated, which meant I couldn't handle certain textures, and freaked out at loud noises," Woody wrote in his essay. "I also had problems managing tasks with multi-sensory inputs, like handwriting and catching a ball. These sensory problems meant that sports, driving, and concerts would all be things I couldn't ever do or see without a great deal of difficulty."

For Woody, the diagnosis of sensory processing disorder, or SPD for short, came very early, at age 4. His mother, Pam Sims, had arranged for him to be tested for his school's gifted program. It was the tester who informed her that he believed her son fit the bill for the disorder.

"We thought his physical development stuff was more related to his height," said Pam Sims, now 52, of Denver, Colo. "We didn't know anything about sensory processing disorder."

In a coincidence that Pam Sims calls a "luck of the draw," a center devoted to the research and treatment of this disorder happened to be located in Denver, where they live. It was here, at the STAR Center, that Woody engaged in sensory-based therapies aimed at improving his coordination and social and interactive therapies to help him deal with stimuli in his environment that he found harsh and jarring.

"It is amazing what it did for him," Pam Sims said. "As time went on, we had more treatments. We stopped when he was about 7 or 8 years old, as he had learned to regulate himself."

Stories like Woody's appear to support the existence of SPD -- and there are many such stories. Nevertheless, solid research confirming the existence of SPD is in far shorter supply, many in the medical community say. And on Monday, it would seem that new recommendations from the American Academy of Pediatrics have dealt another blow to the legitimacy of SPD. Specifically, the AAP recommends, "At this time, pediatricians should not use sensory processing disorder as a diagnosis."

The recommendations also suggest to pediatricians that they inform families that the evidence for sensory-based therapies is limited and that outcomes from these therapies should be monitored closely.

"I think the academy statement reinforces the decision that there is not enough information at this time to conclude that this is a distinct disorder," said Dr. Michelle Zimmer, a professor in the UC Department of Pediatrics and a lead author of the recommendations. "Moving forward, there needs to be a lot more research in this field."

Dr. Larry Desch, director of developmental pediatrics at Advocate Health Care and also a lead author on the recommendations, said that he did not anticipate that the recommendation would be well-received among parents and doctors who believe sensory processing disorder should have its own place as an official condition.

"I think they'll be unhappy, some of them," he said. "But I'm hoping it will lead to more research studies being done."

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Bay Area arts and entertainment picks, May 27 | Bullitt Central Band

More info?
S MUSIC Trannyshack: Madonna Tribute The award-winning drag show salutes the Material Girl in a production that incorporates everything from lowbrow trash to highbrow performance art. Performers include Heklina, Exhibit?

Music


Bay Area arts and entertainment pick, May 27

Pygmalion: Henry Higgins (Clive Worsley) wins a bet that he can transform poor flower seller Eliza Doolittle (Ginny Wehrmeister) into a lady, but he never counted on her having a mind of her own. Town Hall Theatre?


What's new in arts and entertainment, May 20

Benefit West Coast Blues for a Cure With Irma Thomas , Yoshi's San Francisco (Sun.). Movies Opening Friday Chernobyl Diaries (R), Jesse McCartney, Jonathan Sadowski. Hysteria (R), Maggie Gyllenhaal, Hugh Dancy. Keyhole (?

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Monday, May 28, 2012

Sony Ericsson G900 Theme:Vaio V1

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Compatible with G700,G900,P1,W960,M600 & similars

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Mamasource: 90% off Entertainment Wkly, Dave Ramsey Financial Peace University, Baby Genius Deals

baby dealsHead over to Mamasource?and find a handful of nice daily deals with big savings!

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Case-Mate?s Fancy New iPad 3 Line-up

Your Vote:

VN:F [1.9.15_1155]

Memorial Day Sale- Save 20% on all orders through May 31st using coupon code MDAY2012!Updated With New Hands-On Photos! Recently Case-Mate has been impressing us here at iPad Accessories with their great selection of stylish and functional cases at great prices. Case-Mate has been around for a while as an iPad Accessory manufacturer and their stylish cases are always interesting and innovative. Their design teams seem to have no end to clever ways to combine interesting materials and interesting colors together to make something unique and good looking. We received a number of the new Case-Mate iPad 3 accessories to review and we have posted our thoughts and hands-on photos inside. Check out the new lineup and see which cases impressed us most!


Venture Case

Venture Case
We?re big fans of the Venture Case for the iPad 2, so we?re imagining the Venture case for the iPad 3 is even better! This folio-style case wraps your iPad in leather-inspired material with tactile textured finishes. A camera cut-out provides your iPad with an unobstructed view for picture taking and video making. The innovative stand design lays flat against the case when not in use and pops out in a snap when needed! The cover contains magnets that work the iPad?s on/off switch natively letting you save your iPad?s battery for important bird smashing or fruit swiping! The case comes in two great color combos: black on black, and dark brown on light brown. If you?re looking for a functional, professional case be sure to check out the Venture Case out!


POP! Case With Stand

POP! Case
Looking for solid protection while still giving easy access to the iPad?s screen? Look no further than the POP! case. the POP! case featured a strong, molded plastic shell coupled with soft rubber internals to cushion and cradle your iPad from inadvertant shocks and drops. Rubber sides give a solid grip on the iPad and slightly raised rubber frame keep the screen of the iPad off of surfaces even when placed face down! The case comes with an integrated stand that props the case and iPad in either portrait or landscape orientation, perfect for watching videos or playing games. The Case-Mate POP! comes in a very nice white and gray color combo, perfect for those of your who opted for the white iPad. More color combos are planned so be sure to check sign up for Case-Mate?s mailing list. The POP! can be bought direct from Case-Mate here.

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Stingray Slim Stand

Stringray Slim Case
For the adventurous iPad accessories enthusiast comes an eclectic case from Case-Mate: the Stingray Slim Stand case. Featuring stingray embossed leather in two bold colors: turquoise blue and lipstick pink this case is sure to stand out! Speaking of standing out, the smart-magnetic compatible cover folds neatly into a stand via the innovative tab located on the back of the case. Cutouts for all the iPads buttons and ports encircle the case and a camera hole allows unobstructed access to picture taking even on the most extreme adventures. For those looking for something special be sure to check out the Stingray Slim Stand now!


Screen Protector Kit

Screen Protector Kit
No matter what case catches your fancy, Case-Mate or not, the screen protector kit is here to give your iPad that final layer of scratch and scuff protection. Consisting of a tough self-adhesive polymer, the anti-glare and anti-fingerprint screen protector installs and removes easily from your iPad. The kit comes with everything needed to install and keep your protector looking and functioning its best; a soft applicator card, a screen cleaning cloth and the full faced screen protector. The kit is compatible with both the iPad 2 and the new iPad 3. Be sure to give your iPad an extra dose of screen protection with the screen protector kit by Case-Mate today!

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Sunday, May 27, 2012

NFL union files suit against league over 2010 cap

The players union claimed Wednesday that the NFL imposed a secret salary cap during the uncapped 2010 season that cost the players at least $1 billion.

The complaint was filed in U.S. District Court in Minneapolis, which oversees the Reggie White settlement covering NFL labor matters. But the league says the union has no grounds for the action and is prohibited from filing it by the collective bargaining agreement.

The complaint claims a "conspiracy" to set a $123 million salary cap for the 2010 season, when owners did not have the authority to do so. The Cowboys and Redskins have had their future salary caps lowered for overspending in 2010, Dallas by $10 million over two seasons, Washington by a whopping $36 million.

Both teams lost a grievance against those reductions on Tuesday.

"When the rules are broken in a way that hurts the game, we have an obligation to act. We cannot stand by when we now know that the owners conspired to collude," union chief DeMaurice Smith said Wednesday.

In response to the reopening of the Reggie White lawsuit, NFL spokesman Greg Aiello said, "There was no collusion. There was no agreement. These claims are totally unfounded."

A league statement said the collective bargaining agreement signed last August to end the 4 1/2-month lockout prohibited the filing of these claims, and that players' attorneys signed a separate agreement agreeing to the terms.

But NFLPA outside counsel Jeffrey Kessler said that agreement was rejected by the court.

"The document they are referring to was not accepted by the district court in Minnesota," he said Wednesday. "It was rejected and the court entered an order which only dismissed claims under White that were pending."

The NFL also points to a clause in the latest labor contract in which the union gives up the right to sue over "collusion with respect to any League Year prior to 2011."

Thus, the NFL has considered the 2010 uncapped season a closed matter ever since the new labor deal was signed last summer. Clearly, the players do not, and now are seeking compensation for lost wages caused by collusion among the teams.

"Our union recently learned that there was a secret salary cap agreement in an uncapped year," NFL Players Association President Domonique Foxworth said. "The complaint today is our effort to fulfill our duty to every NFL player. They deserve to know, above all, the facts and the truth about this conspiracy."

The 2006 CBA included an uncapped 2010 season as the final year of the deal. It was thought that neither the league nor the union would want the potential chaos of a season with no salary cap, but that proved false as negotiations on a new contract stagnated.

Just over two months after that uncapped season, the league locked out the players in March 2011. The salary cap was reinstated in the new, 10-year CBA finalized last August.

But on March 12, just before free agency began, the Redskins and Cowboys had their salary caps reduced over the next two seasons. The NFLPA was involved in that process, with 28 other clubs getting a boost in their salary caps for 2012 and '13.

Oakland and New Orleans do not share in the redistributed salary cap space because they engaged in similar practices, but not to the degree of Washington and Dallas.

The union now believes Dallas and Washington were punished for exceeding a covert salary cap in 2010, not for undermining competitive balance, as the NFL has claimed.

"The league expressed their view that they thought those teams had gotten a competitive advantage," Kessler said. "If we wanted other salary cap increases for the clubs (in 2012) ... the price for doing that was doing this salary cap reallocation.

"Had the union known about prior collusion, the union would never have agreed to these cap reallocations."

The union says the league office approved contracts enabling the Redskins, Cowboys, Raiders, and Saints to exceed that "secret, collusive salary cap."

This is dangerous territory for any sport.

In baseball, the union filed collusion grievances following the 1985, 1986 and 1987 seasons accusing management of conspiring against free agents. After arbitrators ruled in the union's favor, management agreed to a $280 million settlement. Among the players affected were Jack Morris, Andre Dawson, Tim Raines, Jack Clark and Lance Parrish.

A triple-damages provision was inserted into the sport's labor contract in 1990.

This case is not comparable to baseball's, according to Gary Roberts, dean at the Indiana University Robert H. McKinney School of Law.

"With baseball players it was strictly a matter for arbitration," Roberts said, "where here the union is alleging a violation of the White class action. Procedurally and substantively the claims are not that similar.

"The union's problem is not in the merits of their argument, it's in the procedural part of it. They signed a CBA that said all litigations are settled. What they're saying now is that only applied to things that 'we were aware of. We only waived and settled all claims that we knew existed. We couldn't be asked to waive any claims that we did not know existed.' "

???

AP Sports Writers Rachel Cohen in New York and Jon Krawczynski in Minneapolis contributed to this report.

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Egypt candidates court undecided voters

Egypt's presidential election frontrunners were vying for deals with rival candidates Sunday in a bid to appease a polarised nation that will choose between an Islamist and a Mubarak-era minister in a June runoff.

Final votes were still being counted, but unofficial results suggested that the top two candidates were the Muslim Brotherhood's Mohammed Mursi and Ahmed Shafiq, a former premier under ousted president Hosni Mubarak.

Middle ground votes were up for grabs, with both candidates since Saturday shuttling between meetings with different political forces, as they compete for the mantle of the revolution that ousted longtime president Hosni Mubarak in 2011.

"The race for the coalitions has begun," read the headline of the state-owned Al-Ahram newspaper.

On Sunday, share prices on the Egypt Exchange declined 3.49 percent with the main EGX-30 index slipping to 4,789.14 points.

"The first results of the presidential election have added to the political nervousness and uncertainty for the future," financial analyst Mostafa Saad told AFP.

The Brotherhood called a meeting of various candidates on Saturday afternoon, but the campaigns of Abul Fotouh, former foreign minister Amr Mussa and Nasserist candidate Hamdeen Sabbahi said the three would not attend.

According to a tally by the Islamist group, Mursi had won 25.3 percent of the vote and Shafiq 24 percent, with Sabbahi at 22 percent.

Sabbahi said he would refuse any offer to become vice president, and told AFP he would file a complaint over electoral irregularities that may affect the result of the first round.

On Saturday, Mursi appealed to Egyptians to pursue the goals of the revolution, a day after his movement said the nation was "in danger."

He said he was confident the results of the June 16-17 runoff "will serve the revolution and the interests of the Egyptian people."

He also sought to reassure secularists and the country's Coptic Christian community which makes up around 10 percent of the 82 million population.

"As president, I will be the president for all Egyptians. (My relationship) with the Brotherhood will be the same as all Egyptians," he said.

On Friday night, the Brotherhood said it was seeking to create a coalition of forces to challenge Shafiq.

"We call on all sincere political and national forces to unite to protect the revolution and to achieve the pledges we took before our great nation," it said.

Shafiq also called for broad support from former rivals, calling on his competitors by name to join him and promising there would be no return to the old regime.

"I reach out to all the partners and I pledge that we would all work together for the good of Egypt," he told a news conference.

Addressing young people who spearheaded the 2011 revolt, he said: "Your revolution has been hijacked and I am committed to bringing (it) back.

"I pledge now, to all Egyptians, we shall start a new era. There is no going back."

As the top two candidates worked to rally support for the runoff, leftist candidate Sabbahi, who came third, said he was to file a complaint over alleged voting irregularities in the first round.

"We will file appeals and we will then determine whether or not we accept the results," Sabbahi said.

A Shafiq-Mursi runoff looks likely to further polarise a nation that rose up against the authoritarian Mubarak 15 months ago but has since suffered endemic violence and a declining economy.

The contest presents a difficult choice for activists who led the revolt against Mubarak. For them, choosing Shafiq would be to admit the revolution had failed, but a vote for Mursi could threaten the very freedoms they fought for.

Many who voted in the first round "will not know who to vote for in the runoff. Some will not vote at all, because they believe that morally they can't support Shafiq or Mursi," writer Khaled al-Khamissi told AFP.

On Saturday, former US president Jimmy Carter, whose Carter Centre monitored the elections, told journalists that the process had been "encouraging" but noted that he and his monitors had faced unprecedented constraints.

"I would say that these (elections) have been encouraging to me," he said, adding that authorities had imposed "constraints placed on us as witnesses that have never been placed on us before."

He said minor "haphazard" violations had been observed, but there did not appear to be systematic irregularities that favoured any one candidate.

The election follows a tumultuous military-led transition from autocratic rule marked by political upheaval and bloodshed, but which also witnessed free parliamentary elections.

Mubarak faces a verdict on June 2 to determine whether or not he was involved in killings of protesters during the 18-day revolt.

On Sunday, his longtime chief of staff, Zakaria Azmi, was sentenced to seven years in jail on corruption charges.

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Ex-NFL player Reggie Rucker: Concussions were funny then, not now | ProFootballTalk

reggieruckerGetty Images

Reggie Rucker played wide receiver in the NFL from 1970 to 1981, and he says that in his playing days, the culture of the league as it related to head injuries was to treat the whole thing as a joke.

Rucker told the Cleveland Plain Dealer that players routinely returned to games after suffering hits serious enough to cause memory loss, and that players thought it was funny when they?d watch film of a game they couldn?t remember playing in.

?I remember when I was in Oakland and got knocked out by Jack Tatum,? Rucker said. ?I remember [trainers] asking, ?Do you know where you are?? I said, ?Oakland, California.? You sat down for a while, and then you went back in. You?ve been programmed all your life as a professional athlete, particularly in my era, that you could not give in. You had to show your bravado. The next day, when you went back to review the game on film, I?m sitting there and watching something I couldn?t remember. You?re laughing and joking and it?s funny then. It?s not funny now.?

Rucker is one of the more than 2,200 former players suing the NFL, and he thinks the league owes it to those players who laughed through their concussions to take care of them now.

?I?m not angry,? he said. ?I?m not vindictive. But I do want my life to be cared for in the appropriate way, if something happens to me as a result of those concussions and those hits, so that I?m not a burden to society or to my family.?

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Saturday, May 26, 2012

Greek euro exit would be a recipe for hardship

Signs advertising that each item of merchandise is on sale for one euro are seen in a discount shop in central Athens on Friday, May 25, 2012. Uncertainty over Greece's future in the eurozone has hammered markets ahead of June 17 general elections in the crisis-hit country. The Greek share index touched new 22-year lows, dipping below 500 points on Friday. (AP Photo/Thanassis Stavrakis)

Signs advertising that each item of merchandise is on sale for one euro are seen in a discount shop in central Athens on Friday, May 25, 2012. Uncertainty over Greece's future in the eurozone has hammered markets ahead of June 17 general elections in the crisis-hit country. The Greek share index touched new 22-year lows, dipping below 500 points on Friday. (AP Photo/Thanassis Stavrakis)

A sign advertising that each item of merchandise is on sale for one euro is seen in a discount shop in central Athens on Friday, May 25, 2012. Uncertainty over Greece's future in the eurozone has hammered markets ahead of June 17 general elections in the crisis-hit country. The Greek share index touched new 22-year lows, dipping below 500 points on Friday. (AP Photo/Thanassis Stavrakis)

ATHENS, Greece (AP) ? As Greece creaks under its untenable debt and a shrinking economy, the possibility that it could stop using the euro is becoming increasingly likely. The effects of such a move would be as quick as they would be brutal for ordinary Greeks, who would essentially take a 50-percent pay cut just as prices soar.

Here's a look at what else could happen:

THE RETURN OF THE DRACHMA

No other country has ever left the 17-country eurozone before and there are no procedures in the EU's vast rulebook that would push any country out. But one fear is that the Greeks could decide to vote in an anti-austerity government on June 17 that may then decide to renege on the terms of the multi-billion-euro bailout which has been keeping the country afloat. Greece could be then forced into a messy exit from the euro bloc. It would then have no choice but to start printing its own currency ? the drachma ? to pay its way.

According to the Greek think tank Foundation for Economic and Industrial Research (IOBE), such a move would hit the Greek people hard ? and quickly. The new drachma would lose half or more of its value relative to the euro. This would drive up inflation and sap the purchasing power of the average Greek. At the same time, the country's economic output would drop, putting more people out of work where one in five is already unemployed. The prices of imported goods would skyrocket, putting them out of reach for many.

THE DASH FOR CASH

The prospect of Greece leaving the euro and dealing with a devalued drachma has already prompted many people to start withdrawing their euros out of the country's banks.

"Fear has gripped many who are withdrawing their money," said IOBE head of research Aggelos Tsakanikas.

Although the latest bank deposit figures aren't yet available, Greek President Karolos Papoulias last week said about ?700 million ($898 million) in deposits was taken out of banks the week after the May 6 election. What's more, according to central bank data, Greek banks have been hemorrhaging money for almost three years now ? from a high of ?237.8 billion ($302.5 billion) worth of deposits in Sept. 2009 down to ?165.3 billion ($210.3 billion) in March this year.

A victory for anti-bailout lawmakers in the June 17 election would likely trigger an even bigger bank run, said Dimitris Mardas, associate professor of economics at the University of Thessaloniki. Greek authorities, Mardas predicts, would respond by imposing controls on the movement of money for as long as it takes for the panic to subside.

WHAT ABOUT HOMES AND SAVINGS?

As the new drachma quickly loses its value against other currencies, ordinary Greeks' savings and pensions will shrink just as rapidly. Analyst Vangelis Agapitos estimates that inflation under the new drachma would quickly reach 40 to 50 percent to catch up with the fall in the new currency's value. This would make everything much more expensive.

"People are going to need five times the amount of money they would have needed to purchase something," Agapitos said.

To stop the falling value of the drachma, interest rates would have to be increased to as high as 30 to 40 percent, according to Agapitos. People will then be unable to pay off their loans and mortgages and the country's banks would have to be nationalized to stop them from going under, he predicts.

FEW BENEFITS FOR BUSINESS

Some Greeks believe quitting the euro would boost the country's economy as a devalued drachma would make Greek exports cheaper.

But Constantine Michalos, president of the Athens Chamber of Commerce and Industry, says Greece doesn't have a strong enough export-oriented economy to take advantage of a devalued currency. The country currently imports twice as much as it exports.

"Without any real heavy industry, the Greek economy can't exploit this advantage," Michalos said. "Our main industry is tourism, but in a chaotic situation, which tourist would choose to come to Greece right after the country goes back to the drachma?"

To get its international bailouts, Greece had to embark on a series of economic and market reforms such as reducing a bloated public sector and cutting red tape. Agapitos warns that if Greece dumps the euro, the incentive to carry out these reforms would evaporate, hurting Greece's competitiveness.

GETTING IT ON THE BLACK MARKET

A drachma that is dwindling in value means that even basic, foreign-produced goods such as medicines or fuel will cost much more. Almost inevitably, a thriving black market would emerge, taking more steam out of the economy just as bank loans become much more difficult to pay off.

Vangelis, a 58-year-old former customs official who didn't want to give his full name, worried that going back to the drachma would return Greece to the abject poverty of 1940s when it was under Nazi occupation.

"We'll be paying half our salary for a can of olive oil ... Greeks can't be thinking about returning to the drachma. It would be a catastrophe, a catastrophe," Vangelis said.

TURNING TO A LIFE OF CRIME?

With all the pain a drachma-based economy would induce, IOBE head of research Aggelos Tsakanikas foresees an increase in crime as people struggle to pay bills. "We won't see tanks in the streets and violence, we won't see people starving in the streets, but crime could very well rise," he said.

Others reject the apocalyptic scenarios altogether, saying Greeks will fall back on their resourcefulness to overcome hard times and lend a hand to those less well off.

"The way things are now, it can't get any worse," says Athens resident Tasos Schinas, 37. "Sure, the transition to the drachma will be difficult (but) average people will find a way to survive, many will probably go back to the village and start growing produce ... We just won't go back to the lifestyle we've led all this time."

Agapitos, the analyst, thinks that attitude is too cavalier.

"Desperate people do desperate things, but I can't predict what will happen," he said. "There will be rage and people will want to vent it but it may not be done in a civilized way."

Associated Press

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USC men reach NCAA tennis final

The top-seeded USC men's tennis team defeated rival UCLA, 4-1, in a wild NCAA semifinal at Athens, Ga., and earned a chance to win its fourth consecutive national championship Tuesday. The Trojans (32-1) will meet third-seeded Virginia at 2 p.m. PDT in Athens. USC beat the Cavaliers in last year's final.

Virginia defeated seventh-seeded Pepperdine to reach the championship match. Lightning and thunder interrupted action midway through the first sets of both semifinal matches, forcing them to move indoors to be played out on two courts apiece.

On the women's side, top-seeded UCLA earned a thrilling 4-3 victory over fifth-seeded USC in Athens. The Bruins (26-2) will face second-seeded Florida (26-1) on Tuesday at 10 a.m. PDT. The Gators advanced to the final with a 4-3 win over third-seeded Duke.

::

Rafael Nadal showed he's still the man to beat on clay, defeating Novak Djokovic, 7-5, 6-3, Monday in a rain-delayed final at Rome to win his record sixth Italian Open and regain the No. 2 ranking.

After losing to Djokovic in seven straight finals ? including Rome last year ? Nadal has now won two straight against the top-ranked Serb after also capturing the Monte Carlo Masters on clay. Nadal also moved ahead of Roger Federer in the rankings with the French Open starting Sunday.

Djokovic, drained in Monte Carlo after the death of his grandfather, made 41 unforced errors in this match. His double-fault on the last point gave Nadal the 49th title of his career and his 35th on clay.

Nadal did not drop a set all tournament to clinch his third Italian Open victory in four years.

ETC.

Ex-NFL players, wives file concussion lawsuit

Thirteen former football players and five of their wives filed a civil lawsuit in Los Angeles Superior Court against the NFL and helmet manufacturer Riddell, seeking damages for injuries and financial losses they incurred allegedly from concussive brain injuries sustained during the players' professional careers.

The plaintiffs include former USC receivers Johnnie Morton and John Jackson and former UCLA receiver Mike Sherrard.

The suit says the NFL and other defendants "deliberately ignored, misrepresented and actively concealed" information regarding the damaging effects of repetitive concussive brain injuries.

::

The Tampa Bay Buccaneers traded tight end Kellen Winslow to the Seattle Seahawks for a draft pick and signed former Indianapolis Colts star Dallas Clark to replace him.

Earlier in the day, Winslow told SiriusXM radio that first-year Coach Greg Schiano was "kind of upset" that Winslow had not been working out with the team during the off-season.

::

Riverside welterweight Josesito Lopez verbally agreed to replace Andre Berto and fight former world welterweight champion Victor Ortiz of Oxnard on June 23 at Staples Center, Lopez's promoter, Dan Goossen, said.

Lopez (29-4, 17 knockouts) was summoned after it was announced Friday that world welterweight champion Berto tested positive for the steroid nandrolone.

?Lance Pugmire

::

It appears as though the Ducks found a solution for the heavy workload starting goalie Jonas Hiller endured this season, their search for a quality backup winding up in Sweden.

On Monday, they signed goaltender Viktor Fasth to a one-year contract worth $1 million. His contract is a one-way deal. The 29-year-old has been named the Swedish Elite League's goaltender of the year the last two seasons. With AIK Stockholm, he had five shutouts with a 2.12 goals allowed average and .931 save percentage in 46 games last season.

?Lisa Dillman

::

Former West Virginia football coach Bill Stewart, who was hailed as Rich Rodriguez's successor but wound up leaving the school in a messy split, died Monday of what athletic department officials said was an apparent heart attack. He was 59.

Stewart's family notified the university and said Stewart had been out golfing with the longtime friend who hired him as head coach, former athletic director Ed Pastilong. West Virginia spokesman Michael Fragale said he had no further details, and Pastilong couldn't immediately be reached for comment.

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'40 tons' of tsunami debris litters Alaska island

Buoys, bottles and cans believed to be from the Japan tsunami are surfacing in Washington State, Alaska and British Columbia, and scientists say the mess will be there for generations. NBC's Miguel Almaguer reports.

By msnbc.com news services

ANCHORAGE, Alaska -- Cleanup workers?will on Friday?attack a jumble of debris from Japan's 2011 tsunami that litters an Alaskan island, as residents in the state gear up to scour their shores for everything from buoys to building material that has floated across the Pacific.

The cleansing project slated to start on Montague Island is expected to last a couple weeks, and organizers say it marks the first major project in Alaska to collect and dispose of debris from the tsunami.


The March 2011 tsunami, caused by a magnitude 9.0 earthquake, killed nearly 16,000 people and left over 3,000 missing on Japan's main island of Honshu, and precipitated a major radiation release at the Fukushima Daiichi nuclear plant.

AP

View side-by-side the progress that Japan has made since the tsunami and earthquake in March 2011.

A U.S. senator has sought to obtain $45 million to tackle the problem, and officials have cited fears about invasive species and toxic substances thought to be among the floating mess of objects.

Harley-Davidson washes up on Canadian coast

While debris from Japan is also floating toward other U.S. states along the West Coast, Alaska has a more extensive shoreline, much of it difficult to reach.

'Just a start'
Montague is an uninhabited island at the entrance to Prince William Sound, southeast of Anchorage. About a dozen volunteers and employees from the environmental group Gulf of Alaska Keeper and the Center for Alaskan Coastal Studies will handle the debris-removal project at the island.

"We'll probably remove 30 to 40 tons from there. That's just a start," said Patrick Chandler, special programs coordinator for the Center for Alaskan Coastal Studies.

Japan has estimated 5 million tons of debris was swept out to sea, but that most of it sank, leaving 1.5 million tons floating. Still, those figures are rough estimates, said the National Oceanic and Atmospheric Administration.

Several citizens on Alaska's coastline are surprised by the tsunami debris that has been washing up on the beaches. KTUU's Ted Land reports on objects now found on Kayak Island from buoys and nets to food containers with Japanese writing.

Observers flying over the Alaska coast have spotted, among other items, huge numbers of barrel-sized polystyrene foam buoys, often associated with Japanese oyster farms.

Tiny specks of polystyrene foam that break away from larger objects can be dangerous to seabirds or marine mammals, because they resemble eggs or other food morsels, Chandler said.

Japanese teen traced as owner of soccer ball found in Alaska

Another worry is that floating debris might carry invasive species, such as barnacles, that would wreak havoc in waters off Alaska and the U.S. West Coast, said Doug Helton, the Seattle-based coordinator of NOAA's office of response and restoration.

Then there is the danger from noxious substances in partly full fuel jugs, cleanup organizers said.

Last month, the U.S. Coast Guard sank a 164-foot fishing boat from the Japan tsunami that drifted near Alaska. The Coast Guard said the so-called "ghost ship" was a navigational hazard.

Tracking the debris from the Japan tsunami can be tricky, as it moves across the Pacific via ocean currents and winds. NBC's Miguel Almaguer reports.

With more debris headed for the West Coast, questions about cleanup costs remain unanswered. Those expenses could be high in Alaska because of geographic and weather challenges.

U.S. Senator Mark Begich of Alaska suggested last week that NOAA provide $45 million as an initial outlay to fund what is expected to be a sustained and difficult beach cleanup.

Meanwhile, David Baxter, a technician who works at a Federal Aviation Administration station on the uninhabited Middleton Island in the Gulf of Alaska, has made some notable finds on his rounds in his hobby of beachcombing.

An earthquake, a tsunami, a nuclear meltdown -- residents of Japan's northeast coast suffered through three intertwined disasters after a massive 9.0 magnitude temblor struck off the coast on March 11, 2011.

Earlier this month, the owner of a tsunami-wrecked restaurant in the coastal Miyagi Prefecture spotted one of her buoys among Baxter's debris photos posted online. The yellow buoy was part of the restaurant's sign, he said.

Baxter has arranged to send it back to the woman. "Now that her buoy's found, she's going to rebuild," he said.

On Wednesday,?the World Health Organization said increases in radiation linked to the Fukushima?disaster?were below cancer-causing levels in nearly all of Japan.

The agency's 124-page report also says neighboring countries had levels similar to normal background radiation and for the rest of the world there was some minor exposure through food.

The U.N.'s International Atomic Energy Agency had previously confirmed that radiation levels in some Japanese milk and vegetables reached significantly higher levels than Japan allows for consumption.

Reuters and The Associated Press contributed to this report.

More world news from msnbc.com and NBC News:

Follow us on Twitter: @msnbc_world

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The Volkswagen Golf GTI goes topless

22 May 2012 | Car News, Volkswagen | 21 views

?

For all those enthusiasts who wondered what ever happened to the idea of a Golf Cabrio, the officials at Volkswagen have?a little surprise up their sleeve. For the first time since the first generation, Volksvagen?presented the first videos as well as a bunch of new photos of a red, topless and steamy?Volkswagen Golf GTI.

To feed that lust a little further, officials say the GTI Cabriolet features?an electricaly powered fabric roof that can be open or close in ~9.5 seconds at speeds of up to 30km/h.

Under the hood the GTI has a 2.0-litre turbocharged four-cylinder engine that generates 210 HP (155 kW ) and 280 NM of torque which will be connected to a six-speed manual or optional six-speed dual-clutch DSG gearbox.?It will be a little slower than the ?roofed? version so accelerating from 0 to 100km/h will be in ~7.3 seconds with a top speed of 237km/h. Fuel consumption will be somewhere around 7.6l/km while CO2 emissions 180g/km.

The return of the topless Volkswagen GTI marks the final variant of the sixth generation Golf ?( before the new model arrives next year ) and the first available models will arrive in dealerships in June.

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Friday, May 25, 2012

Euro crisis turns Spanish suburbs into ghost towns

Pierre-philippe Marcou / AFP - Getty Images, file

Empty buildings in Valdeluz, one of 12 near ghost towns scattered across Spain.

By Ian Johnston, msnbc.com

Just north of Spanish capital Madrid lies Cuidad Valdeluz. Built during the country's economic boom, it was promoted as a suburban family paradise for tens of thousands of people.?

Today, it is one of 12 near ghost towns in Spain, a country that -- despite being the European Union's fifth-largest economy -- is teetering on the brink of a Greece-style meltdown.?


Spain has the highest unemployment rate of all European Union countries at 21.7 percent, according to a report published this month by the Center for Economic and Social Rights. Among those aged under 25, nearly half -- 46.4 percent --?are without a job. More than half a million households had no one earning an income in 2011.

NYT: One-fifth of Spain's GDP is?now black market

The report warned that "over half the population reports experiencing a heavy financial burden due to housing costs." The number of foreclosure proceedings rose from 25,953 in 2007 to 93,319 in 2009, an increase of nearly 260 percent.

As she stood on the deserted streets of Valdeluz, journalist?Lindsey Hilsum of the U.K.'s Channel 4 News?said?the suburb?illustrated just how far and how fast Spain had fallen.

On the streets of Madrid, they have a message for the leaders meeting in Brussels: stop cutting and start promoting growth. For them, the Spanish government decision to recapitalise Bankia, the country's fourth largest lender, while reducing education spending by 20 per cent, was the last straw.

"This was the Spanish dream: new developments, luxury apartments, the good life. But it was all on borrowed money. Now the developers have lost their investments, the banks are in crisis, and increasing numbers of Spaniards are homeless," she said.

Homeless and 'in debt forever'
Maria Francisca Cano Munoz, Jesus Munoz Alcaza, their daughter and disabled son are among those about to lose their home.

CNBC's Simon Hobbs discusses the euro's decline and whether Greece will leave the euro, with CNBC's Michelle Caruso-Cabrera and Bob Pisani.

"We are going to end up with no home and in debt forever," Munoz Alcaza, an unemployed construction worker, told Hilsum through a translator. "We'll have to keep paying for this apartment, but we won't be able to live in it."

Greece's debt woes put Europe on financial knife edge

"At first they [bank officials] were nice and said 'Don't worry, you can pay at the end of the month to avoid interest,'" Cano Munoz added. "But when you cannot pay at all, suddenly you are a bad person and 'there's the door... go!'"

As in Greece, politicians are looking to economic powerhouse Germany for help.

Many residents fear that a slow economy is cutting into the number of foreign visitors. NBC's Stephanie Gosk reports.

"Germany has got a lot of profit from the euro [currency]. Because Spain was rich, we bought many things that were made in Germany," an independent deputy in Spain's congress, Irene Lozano Domingo, told Hilsum.

"We are all linked, so if we are going to hell, they are coming with us. This is what they have to see," she added.

Greeks withdraw $894 million in a day: Is this beginning of a run on banks?

Like other countries, Spain has bailed out its banks and slashed government spending. But the economy is now so bad that some are thinking of quitting the country altogether.

"I don't know. Latin America somewhere? Brazil, Mexico ... somewhere where it's going up, you know?" a protester at a recent demonstration against education cuts told Hilsum.

The euro is hitting its lowest level since July 2010. Discussing the impact the weak euro has on the global economy, with Larry McDonald, Newedge Group and John Spallanzani, GFI Group.

European Union leaders concluded their latest summit early Thursday with few concrete steps to fix the continent's festering financial crisis, Reuters reported.

One problem has been the need to get agreement between either the 17 EU countries that use the euro as their currency or all 27 member states.

"I think about my one Congress, then I start thinking about 17 congresses and I start getting a little bit of a headache,"?Barack Obama said following the recent NATO summit in Chicago.

The president's headache could get substantially worse, according to a report by the Organisation for Economic Co-operation and Development. It warned Tuesday that while the U.S. and Japan were leading a fragile economic recovery among developed countries, they could be blown off course by the European debt crisis.

'Vicious circle': Europe crisis threatens world economy, OECD says

The biggest continuing fear is that if Greece cannot be saved, other larger economies ? like Spain or Portugal ? might face the same fate.?

The leaders gathered in Brussels recognized that Greece had endured significant hardships and promised to release development funds aimed at spurring growth, Reuters reported.?

But Luxembourg Prime Minister Jean-Claude Juncker told reporters that the euro countries "have to consider all kinds of events," the news service added.

Europe told to prep for Greek exit scenario

Juncker insisted early Thursday that he had not asked the euro nations to prepare national contingency plans for a possible chaotic departure of Greece from the currency, saying?the "the working assumption" was that Greece would remain part of the euro.

But his?statement was also a frank admission that Greece could wind up abandoning the euro.

A new election is scheduled for June 17, as debate continues over the country's place in the euro zone. NBC's Stephanie Gosk reports.

Greece's fringe political parties, which are threatening to renege on commitments made to secure bailout loans, saw their popularity surge in recent elections. No party has been able to form a government, and the country will vote again June 17.?

Germany's Pirate Party rides wave of popularity

Many analysts have said that Greece, already in its fifth year of recession, has no hope of recovery if it sticks to the spending cuts and tax hikes it agreed to in order to secure bailout loans.?

"We want Greece to remain in the euro area," German Chancellor Angela Merkel said after the meeting, but she also expected the deeply unpopular policies of austerity to continue. "We expect that they will stick to the commitments that they have entered into."?

Ghost towns tell the story of Ireland's faded dream

The perception that European leaders lack the political will to tackle the continent's financial and economic problems has left markets on edge for weeks. Recession is spreading. Banks are under pressure.

Dariusz Kowalczyk, senior economist at Credit Agricole CIB in Hong Kong, said Thursday: "Europe is not doing enough, and the market may not wait for them."?

Reuters contributed to this report.

More world news from msnbc.com and NBC News:

Follow us on Twitter: @msnbc_world

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Devils outlast Rangers, 5-3, take 3-2 series lead

New Jersey Devils' Stephen Gionta, center, celebrates with Ryan Carter, left, and Steve Bernier, right, after scoring against the New York Rangers during the first period of Game 5 of an NHL hockey Stanley Cup Eastern Conference final playoff series Wednesday, May 23, 2012, in New York. (AP Photo/Frank Franklin II)

New Jersey Devils' Stephen Gionta, center, celebrates with Ryan Carter, left, and Steve Bernier, right, after scoring against the New York Rangers during the first period of Game 5 of an NHL hockey Stanley Cup Eastern Conference final playoff series Wednesday, May 23, 2012, in New York. (AP Photo/Frank Franklin II)

New York Rangers goalie Henrik Lundqvist, of Sweden, pauses during the first period of Game 5 of an NHL hockey Stanley Cup Eastern Conference final playoff series against the New Jersey Devils, Wednesday, May 23, 2012, in New York. (AP Photo/Frank Franklin II)

New Jersey Devils' Stephen Gionta, left, celebrates after scoring a goal past New York Rangers goalie Henrik Lundqvist, of Sweden, right, during the first period of Game 5 of an NHL hockey Stanley Cup Eastern Conference final playoff series, Wednesday, May 23, 2012, in New York. (AP Photo/Frank Franklin II)

New Jersey Devils' Stephen Gionta, top center, celebrates with Ryan Carter (20) after scoring a goal against the New York Rangers during the first period of Game 5 of an NHL hockey Stanley Cup Eastern Conference final playoff series, Wednesday, May 23, 2012, in New York. (AP Photo/Julio Cortez)

A shot by New Jersey Devils' Travis Zajac enters the net behind New York Rangers goalie Henrik Lundqvist, of Sweden, during the first period of Game 5 of an NHL hockey Stanley Cup Eastern Conference final playoff series, Wednesday, May 23, 2012, in New York. (AP Photo/Julio Cortez)

(AP) ? The New Jersey Devils never could have imagined they would have a three-goal lead on the New York Rangers less than 10 minutes into Game 5 of the Eastern Conference finals at hostile Madison Square Garden.

Their shock was even greater when that advantage was gone, and they were suddenly locked in a tie game in the opening minute of the third period.

In the end, it all worked out for the Devils, who got another surprising goal from fourth-line forward Ryan Carter in the closing minutes and escaped with a win that put New Jersey on the brink of a spot in the Stanley Cup finals.

Carter's third goal of the playoffs with 4:24 remaining was the difference in the Devils' 5-3 victory over New York on Wednesday night. The Devils have a 3-2 edge in the series, but if the top-seeded Rangers can stay alive on Friday night in New Jersey, Game 7 would be back in Madison Square Garden on Sunday.

"It's a good feeling," goalie Martin Brodeur said of the Devils' status. "We worked really hard to get in that position. (There's been) a lot of unsung heroes and guys producing at different times. Players are playing well. We've just got to keep going.

"Nothing is done yet."

If the Rangers fall short, their best season in years will come to a crashing end and the Devils will move on to face the Western champion Los Angeles Kings. New York hasn't been to the finals since 1994, when the Rangers knocked out New Jersey in the semis and then beat Vancouver for the title.

The Devils are one win away from playing for the Cup one season after their run of 13 straight postseason appearances was snapped. New Jersey went to the finals four times between 1995 and 2003 and won three championships.

"It's a great position to be in," Devils forward Patrik Elias said. "Hopefully, we can play a better game at home. Hopefully, we'll be the team that dictates the energy and the pace out there."

When Travis Zajac scored 9:49 in to make it 3-0, the Devils seemed ready to cruise to victory. But the Rangers roared back and appeared to have every bit of the momentum.

Then the game, and perhaps the entire series, changed in the blink of an eye when Carter put the Devils in front to stay. Zach Parise added an empty-net goal to make sure the Rangers had no chance for another comeback.

Carter had only four goals and four assists in 72 regular-season games with Florida and New Jersey. He has two goals in the East finals.

"They've been great the whole playoffs," Elias said of the fourth line. "It's not always the top guys who win you hockey games."

Stephen Gionta and Elias scored within the first 4:13 before Zajac made it 3-0. Then the Rangers woke up.

Brandon Prust brought New York within 3-1 before the first period was over, and Ryan Callahan made it a one-goal game in the first minute of the second. The Garden really rocked when Marian Gaborik tied it at 3 just 17 seconds into the third.

But the comeback was for naught.

"We probably played our best game of the series," Rangers coach John Tortorella said.

Once Gaborik tied it with an unassisted goal that ricocheted in off Brodeur's skate, it appeared the Rangers would ride the comeback all the way to one of the most stirring wins in team history ? one that would rival victories over New Jersey in the classic 1994 East finals when the Rangers erased a 3-2 series hole behind Mark Messier's guarantee.

Carter made sure it wouldn't happen.

"You have to (keep it together) this time of year," Gionta said. "You have to have a short memory. Fortunately we did and came out with the victory."

New Jersey was outshot 28-17 overall and had only six shots in the third period, but two went in.

Brodeur, the backbone of every New Jersey title, kept his focus throughout the third when he was loudly taunted with chants of "Mar-ty, Mar-ty" after New York got even.

"It was a mistake," Brodeur said of Gaborik's goal. "I'm pretty happy that the boys bounced back and made this a win for us. It would have been tough and people would have blamed that mishandle."

The Rangers were ultimately done in by another terrible start. They had been on a pattern of win-one, lose-one, but now they are on the verge of elimination with their second two-game losing streak in a series this year.

The only time the Rangers have won two straight in a playoff series this postseason is when they overcame a 3-2 hole in the first round and knocked out Ottawa.

"We have to bring all the good things we did and keep doing them in the next game," Rangers goalie Henrik Lundqvist said. "We played really well in the second and third period."

They couldn't say the same about the first.

"It's different when you go down 3-0. You don't have a whole lot to lose," Rangers forward Brian Boyle said. "It was good nonetheless. Now it's 3-2. Now we have to win two. That's the bottom line."

The Rangers burned their timeout early, and Devils coach Peter DeBoer spent his with 10:17 left. Parise implored his teammates on the bench ? "Come on boys!" ? and the messages from the coach and the captain did the trick.

"It wasn't pretty by any means," Parise said. "But we're going home with a 3-2 lead."

Not only didn't the Rangers have the strong start they craved and insisted they needed, they were practically run out of their building.

The same problems that plagued New York in its 4-1 loss in Game 4, when the Devils jumped out to a 2-0 lead in the first period, cropped up again in front of the frustrated fans.

Gionta got the Devils going 2:43 in, and Elias made it 2-0 1:30 later on New Jersey's fourth shot.

Tortorella used his timeout, but it made little difference. He appeared to be calm as he moved back and forth behind the bench while talking to his players. Whatever the message was it didn't sink in.

The Devils shrugged off a few scoring chances by the Rangers, and padded their lead again.

Just 5:26 after Elias' goal, Zajac made it 3-0 with his seventh of the playoffs. Zajac got a clean shot from just inside the right circle that beat Lundqvist inside the left post.

The tide began to turn the Rangers' way, and they allowed only one shot the rest of the period.

Prust, making his return following a one-game suspension for an elbow he delivered to the head of Devils defenseman Anton Volchenkov in Game 3, showed off a bit of scoring touch when he converted on a breakaway with 4:19 left in the first to make it 3-1.

The Rangers outshot the Devils 9-6 in the lopsided period, but continued their sudden defensive dominance well into the second. Then they cut the Devils' lead to a goal just 32 seconds into the second.

New Jersey didn't record its first shot of the period, and its second since its third goal, until Adam Henrique put a puck in on Lundqvist at 6:23.

Lundqvist, who had stopped 94 percent of the shots he faced in the playoffs before Wednesday, made just 12 saves. The Rangers allowed five goals one game after giving up four for the first time in this postseason.

To make the finals, New York will have to win a third consecutive seven-game series.

"We have to have a short memory," Rangers defenseman Ryan McDonagh said. "We've been in this position before in this playoffs and we found a way to get it done. We don't want to look ahead. We have to win two games, but we just have to focus on winning one."

Notes: Brandon Dubinsky had been sidelined since he was injured in the Rangers' victory over Ottawa in Game 7 of the first round. He sat out all seven games of the second round against Washington and the first four against New Jersey. John Mitchell was scratched to make room in the lineup. Prust's return forced D Steve Eminger to sit out after he played the two previous games. ... Ilya Kovalchuk has 10 assists in the playoffs. ... Prust scored his first career NHL playoff goal in his 23rd game.

Associated Press

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Thursday, May 24, 2012

MonitorDaily - Classifieds - Sales - Direct Origination - ? Vice ...

Vice President ? Lease Origination

ATEL Leasing Corporation is one of the largest independent equipment leasing firms in the United States headquartered in the financial district in San Francisco. Since our founding in 1977, ATEL has financed in excess of $3.0 billion of equipment leases. ATEL invests in a wide variety of assets and industries including mining, manufacturing, construction, transportation, energy, rail, and medical.

Job Description: We are seeking sales professionals with a minimum of 3 years of equipment financing or related financial services experience. This person must be capable of arranging and conducting meetings with Fortune 1000 C-level executives. Candidates will need to provide background on the types of transaction closed and historical sales volume.

We are looking for an individual who,

  • Will aggressively work an extensive 30+ year database of ATEL contacts with lessees
  • Will initiate and cultivate new lessee relationships
  • Will travel as required to be successful
  • Has strong financial skills including expertise at calculating lease rates, present values, yields and IRR?s,
  • Possesses innate selling skills but willing to learn strategy and tactics and
  • Works hard and plays hard.
  • A bachelor?s degree is required and a finance emphasis is preferred.

Responsibilities: Director, Lease Origination, responsible for prospecting and closing a minimum of $25 million of equipment lease transactions within a large territory.

The keys to success include:

  • Never say die attitude
  • Disciplined approach to the market
  • Ability to open doors and close deals
  • Knowledge of equipment financing ? including structuring, pricing, accounting, credit, legal and asset management.

We offer a competitive salary, an excellent commission plan, and a standard benefits package.

Please email the following:
1) Resume
2) Three business references

Mari Lynch
600 California St., 6th Floor
San Francisco, CA 94108
(415) 616-3478
mlynch@atel.com

Please visit our website at www.atel.com for more info on our dynamic company.


Date Posted: May 24, 2012?

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Wednesday, May 23, 2012

Better tests for sleeping sickness

Better tests for sleeping sickness [ Back to EurekAlert! ] Public release date: 22-May-2012
[ | E-mail | Share Share ]

Contact: Lies Van Nieuwenhove
lvnieuwenhove@itg.be
32-496-274-434
Institute of Tropical Medicine Antwerp

Lies Van Nieuwenhove, researcher at the Antwerp Institute of Tropical Medicine, has produced proteins imitating typical parts of the sleeping sickness parasite. They can be used in more efficient diagnostic tests, without the need for culturing dangerous parasites.

Each year many thousands of Africans contract sleeping sickness. The cause is a unicellular parasite, a trypanosome, which is transmitted by the bite of tsetse flies. First the parasite multiplies in blood and lymph, while evading the human immune system. It then lodges in organs like heart and kidneys and finally in the brain. Patients become disoriented, their sleeping pattern disintegrates and they get motor and mental problems. This inevitably leads to coma and death. The World Health Organisation estimates that sleeping sickness each year claims 10 000 to 20 000 lives.

In an early stage the disease is easy to treat, but once the brain is invaded, the treatment becomes more complex and one must use medicines with dangerous, even deadly, side effects. So it is important to detect the infection early.

In the regions where Trypanosoma brucei gambiense is found, medical workers for decades already use a rapid diagnostic test, developed at the Institute of Tropical Medicine, to screen millions of people each year on the presence of antibodies in their blood.

But diagnostic test are not perfect: they always will miss cases, or on the contrary they see an infection where there isn't. A bit as the metal detectors at airports: too sensitive and they annoyingly go off on each buckle, earring or coin; a bit less sensitive and pocketknives start slipping trough.

In recent years the number of cases has come down substantially, thanks to campaigns against the disease, so error margins that were acceptable in the old days, because the tests still saved so many lives, now become inadmissible. Research scientist Lies Van Nieuwenhove set out to develop a new and better test.

In such tests one demonstrates the antibodies by presenting them targets they will also recognise and attack on real trypanosomes: typical proteins that cover the parasite as a mantle. When antibody and target react when the test is 'positive' this is made visible by for instance a colour change or a clotting. Today those targets are obtained from living parasites that are raised in laboratory animals, and are a constant danger for the laboratory technicians.

Therefore Van Nieuwenhove tried to synthesise artificial targets, 'mimotopes' that mimic only a part of the original target protein, but still are sufficient to react with the patient's antibodies. She indeed could produce mimotopes that are reliable and give alarm with the right patients. These mimotopes now can be the base for a new generation of rapid diagnostic tests for sleeping sickness.

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Better tests for sleeping sickness [ Back to EurekAlert! ] Public release date: 22-May-2012
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Contact: Lies Van Nieuwenhove
lvnieuwenhove@itg.be
32-496-274-434
Institute of Tropical Medicine Antwerp

Lies Van Nieuwenhove, researcher at the Antwerp Institute of Tropical Medicine, has produced proteins imitating typical parts of the sleeping sickness parasite. They can be used in more efficient diagnostic tests, without the need for culturing dangerous parasites.

Each year many thousands of Africans contract sleeping sickness. The cause is a unicellular parasite, a trypanosome, which is transmitted by the bite of tsetse flies. First the parasite multiplies in blood and lymph, while evading the human immune system. It then lodges in organs like heart and kidneys and finally in the brain. Patients become disoriented, their sleeping pattern disintegrates and they get motor and mental problems. This inevitably leads to coma and death. The World Health Organisation estimates that sleeping sickness each year claims 10 000 to 20 000 lives.

In an early stage the disease is easy to treat, but once the brain is invaded, the treatment becomes more complex and one must use medicines with dangerous, even deadly, side effects. So it is important to detect the infection early.

In the regions where Trypanosoma brucei gambiense is found, medical workers for decades already use a rapid diagnostic test, developed at the Institute of Tropical Medicine, to screen millions of people each year on the presence of antibodies in their blood.

But diagnostic test are not perfect: they always will miss cases, or on the contrary they see an infection where there isn't. A bit as the metal detectors at airports: too sensitive and they annoyingly go off on each buckle, earring or coin; a bit less sensitive and pocketknives start slipping trough.

In recent years the number of cases has come down substantially, thanks to campaigns against the disease, so error margins that were acceptable in the old days, because the tests still saved so many lives, now become inadmissible. Research scientist Lies Van Nieuwenhove set out to develop a new and better test.

In such tests one demonstrates the antibodies by presenting them targets they will also recognise and attack on real trypanosomes: typical proteins that cover the parasite as a mantle. When antibody and target react when the test is 'positive' this is made visible by for instance a colour change or a clotting. Today those targets are obtained from living parasites that are raised in laboratory animals, and are a constant danger for the laboratory technicians.

Therefore Van Nieuwenhove tried to synthesise artificial targets, 'mimotopes' that mimic only a part of the original target protein, but still are sufficient to react with the patient's antibodies. She indeed could produce mimotopes that are reliable and give alarm with the right patients. These mimotopes now can be the base for a new generation of rapid diagnostic tests for sleeping sickness.

###



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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